beneficial effects of a protein rich diet on coping neurotransmitter levels during ampicillin-induced neurotoxicity compared to propionic-acid induced autistic biochemical features

نویسندگان

ramesa shafi bhat department of biochemistry, science college, king saud university, riyadh, saudi arabia.

kaushal kishore. chandrul department of pharmaceutical science, shri venkateshwara university, gajraula, amroha, uttar pradesh, india.

afaf el-ansary department of biochemistry, science college, king saud university, riyadh, saudi arabia.

چکیده

this study examined the effects of a protein rich diet on coping neurotransmitter levels in orally administered ampicillin–induced neurotoxic rats compared with propionic acid (pa) models of autism. 40 young male western albino rats were divided into four groups. the first group served as control and received phosphate buffered saline orally; the second group serving as autistic model was treated with oral dose of pa (250 mg/kg body weight/day for 3 days); the third group was treated with the neurotoxic dose of ampicillin (50 mg/kg for three weeks); the fourth group received the same dose of ampicillin and was fed with special protein rich diets. noradrenaline, dopamine, serotonin glutamate, glutamine and interleukin 6 (il-6) were measured in the brain homogenate of all tested groups. specified doses of pa and ampicillin significantly (p< 0.001) decreased noradrenaline, dopamine, and serotonin levels when compared to control. also glutamate, il-6 levels were significantly (p< 0.001) increased in pa treated group while non-significant increase was found in ampicillin treated group. non-significant increase of glutamine was found in pa treated group with a significant increase in ampicillin treated group. the effects of ampicillin on these parameters were found to be potentiated when the rats were fed on a protein rich diet. our results end with the conclusion that dietary protein level may be a useful tool to find out a path to restrict neurotransmitter alterations in neurodevelopmental disorders like autism.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Beneficial Effects of a Protein Rich Diet on Coping Neurotransmitter Levels During Ampicillin-Induced Neurotoxicity Compared to Propionic-Acid Induced Autistic Biochemical Features

This study examined the effects of a protein rich diet on coping neurotransmitter levels in orally administered ampicillin&ndash;induced neurotoxic rats compared with propionic acid (PA) models of autism. 40 young male western albino rats were divided into four groups. The first group served as control and received phosphate buffered saline orally; the second group serving as autistic model was...

متن کامل

Beneficial Effects of a Protein Rich Diet on Coping Neurotrans-mitter Levels During Ampicillin-Induced Neurotoxicity Compared to Propionic-Acid Induced Autistic Biochemical Features

This study examined the effects of a protein rich diet on coping neurotransmitter levels in orally administered ampicillin-induced neurotoxic rats compared with propionic acid (PA) models of autism. 40 young male western albino rats were divided into four groups. The first group served as control and received phosphate buffered saline orally; the second group serving as autistic model was treat...

متن کامل

Protective and restorative potency of Vitamin D on persistent biochemical autistic features induced in propionic acid-intoxicated rat pups

BACKGROUND Reducing exposure to toxic environmental agents is a critical area of intervention. Prenatal or postnatal exposure to certain chemicals has been documented to increase the risk of autism spectrum disorder. Propionic acid (PA) found in some foods and formed as a metabolic product of gut microbiota has been reported to mediate the effects of autism. Results from animal studies may help...

متن کامل

Therapeutic potency of bee pollen against biochemical autistic features induced through acute and sub-acute neurotoxicity of orally administered propionic acid.

BACKGROUND It is now well documented that postnatal exposure to certain chemicals has been reported to increase the risk of autism spectrum disorder. Propionic acid (PA), as a metabolic product of gut microbiotaandas a commonly used food additive, has been reported to mediate the effects of autism. Results from animal studies may help to identify environmental neurotoxic agents and drugs that c...

متن کامل

Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters

BACKGROUND Propionic acid (PA) found in some foods and formed as a metabolic product of gut bacteria has been reported to mimic/mediate the effects of autism. The present study was undertaken to compare the effect of orally administered PA with that of clindamycin-induced PA-microbial producers in inducing persistent biochemical autistic features in hamsters. The neuroprotective potency of carn...

متن کامل

Beneficial Effects of Silibinin Against Kainic Acid-induced Neurotoxicity in the Hippocampus in vivo

Silibinin, an active constituent of silymarin extracted from milk thistle, has been previously reported to confer protection to the adult brain against neurodegeneration. However, its effects against epileptic seizures have not been examined yet. In order to investigate the effects of silibinin against epileptic seizures, we used a relevant mouse model in which seizures are manifested as status...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
international journal of molecular and cellular medicine

جلد ۵، شماره ۳، صفحات ۱۴۹-۱۵۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023